MICRO AND NANO-ELECTROMECHANICAL SYSTEMS (BIO-MEMS/NEMS) FOR BIOMEDICAL APPLICATIONS
Abstract
Micro and nano-electromechanical systems (Bio-MEMS/NEMS) have emerged as pivotal technologies in the biomedical field, offering the potential for precise diagnostics, targeted drug delivery, and real-time monitoring of biological systems. These systems integrate mechanical, electrical, and biological components at micro- and nanoscale levels, enabling the development of highly sensitive, compact devices. Despite their promise, challenges related to material selection, biocompatibility, and scalability remain critical barriers to their widespread adoption in medical applications. The aim of this study is to explore the potential of Bio-MEMS/NEMS for various biomedical applications, including disease diagnosis, therapeutic interventions, and health monitoring. The research focuses on evaluating the performance, functionality, and biocompatibility of these systems in clinical environments. A systematic review of existing literature and case studies was conducted, focusing on Bio-MEMS/NEMS technologies used in diagnostic devices, biosensors, and drug delivery systems. Experimental data from in vitro and in vivo studies were analyzed to assess device performance and safety. The findings highlight the remarkable capabilities of Bio-MEMS/NEMS, particularly in terms of sensitivity, precision, and integration with biological systems. However, challenges such as biofouling, tissue integration, and long-term stability remain unresolved. Bio-MEMS/NEMS present significant opportunities for advancing medical technologies, but further research is necessary to overcome existing limitations and ensure the safe and effective application of these systems in clinical practice.
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References
Aghajanloo, B., Nazarnezhad, S., Arshadi, F., Prakash Kottapalli, A. G., Pastras, C., & Asadnia, M. (2025). Emerging trends in biosensor and microfluidics integration for inner ear theragnostics. Biosensors and Bioelectronics, 286, 117588. https://doi.org/10.1016/j.bios.2025.117588
Ahmed, W., Mohammad, A. F., Zaneldin, E., Al-Marzouqi, A. H., & AlMazrouei, N. (2025). 8—Synthesis and functionalization methods of polymer nanocomposites for additive manufacturing. In C. M. Hussain & K. Deshmukh (Eds.), Additive Manufacturing of Functional Polymers and Nanocomposites (pp. 201–249). Woodhead Publishing. https://doi.org/10.1016/B978-0-443-26516-7.00008-0
Alrubea, N. A., & Abouelregal, A. E. (2025). Thermoelastic dynamics of viscoelastic nanobeams on elastic foundations under multi-physics interactions. Results in Engineering, 27, 106154. https://doi.org/10.1016/j.rineng.2025.106154
Amarnath, M., Mohite, S., & Palaskar, S. (2025). Recent advances and innovations in textile materials for smart sensor applications: A review. Measurement, 255, 118057. https://doi.org/10.1016/j.measurement.2025.118057
Bakhshi, A., Bakhshi, M., Ahmadi, B., & Rahdar, A. (2025). Chapter 18—Multifunctional theranostic nanomedicine for infectious diseases. In P. Kesharwani & N. K. Jain (Eds.), Theranostics Nanomaterials in Drug Delivery (pp. 339–362). Academic Press. https://doi.org/10.1016/B978-0-443-22044-9.00021-8
Chethan, B., Prasad, V., Sunilkumar, A., Thomas, S., & Sreeharsha, A. (2024). Chapter 6—Design of nanostructured biosensors based on organic and other composite materials. In J. G. Manjunatha (Ed.), Novel Nanostructured Materials for Electrochemical Bio-Sensing Applications (pp. 97–118). Elsevier. https://doi.org/10.1016/B978-0-443-15334-1.00006-7
Deng, N., Ding, X., Ma, X., Shang, H., Xu, J., Cao, K., Chen, K., & Xie, H. (2026). A high-performance piezoelectric MEMS microspeaker with flexible spring-patterned cantilevers. Sensors and Actuators A: Physical, 400, 117522. https://doi.org/10.1016/j.sna.2026.117522
Dey, P., Raza, M. J., Khera, A., Sharma, A., Khajuria, A., Pandey, A., Pandey, C. M., Sharma, R. K., Singh, G., & Barnwal, R. P. (2024). Recent progress of functionalized nanomaterials-based biosensing for monitoring of food- and water-borne pathogens. Environmental Nanotechnology, Monitoring & Management, 21, 100914. https://doi.org/10.1016/j.enmm.2024.100914
Dong, Y., Duan, L., Mao, X., Gu, T., Gu, Y., Yu, H., Zhang, X., Ye, T., Wang, X., Li, P., Wu, J., Wu, H., Fan, K., Hu, L., Wang, F., Tang, L., & Tao, K. (2025). Exploring human motions for smart wearables: Energy conversion, harvesting and self–powered sensing. Nano Energy, 143, 111289. https://doi.org/10.1016/j.nanoen.2025.111289
Fahmy, M. A., & Alharbi, B. M. (2026). Dynamic fracture analysis of functionally graded viscoelastic anisotropic nanostructures with a blunt crack under transient Thermal-Mechanical loading. Theoretical and Applied Fracture Mechanics, 141, 105219. https://doi.org/10.1016/j.tafmec.2025.105219
Gartia, A. K., & Chakraverty, S. (2025). Advanced Computational Modeling and Mechanical Behavior Analysis of Multi-Directional Functionally Graded Nanostructures: A Comprehensive Review. CMES - Computer Modeling in Engineering and Sciences, 142(3), 2405–2455. https://doi.org/10.32604/cmes.2025.061039
Gupta, S., Mishra, V., Aljabali, A. A. A., Albutti, A., Kanday, R., El-Tanani, M., & Mishra, Y. (2025). Breaking barriers in cancer diagnosis: Unveiling the 4Ms of biosensors. RSC Advances, 15(10), 8019–8052. https://doi.org/10.1039/d4ra08212e
Hossain, N., Mahmud, M. Z. A., Hossain, A., Rahman, M. K., Islam, M. S., Tasnim, R., & Mobarak, M. H. (2024). Advances of materials science in MEMS applications: A review. Results in Engineering, 22, 102115. https://doi.org/10.1016/j.rineng.2024.102115
Ismail, G. M., Farea, N. M., Bayat, M., & Wang, J. (2025). Investigation of the highly complex nonlinear problems via modified energy balance method. Journal of Engineering Research, 13(3), 1956–1963. https://doi.org/10.1016/j.jer.2024.07.006
Kim, J., Kumar, A., Bhoyate, S. D., Hwang, J., Jang, H., Mahajan, C., Lee, E., & Gupta, R. K. (2024). Nano Horizons: Exploring the untapped power of two-Dimensional materials. Materials Science and Engineering: B, 310, 117673. https://doi.org/10.1016/j.mseb.2024.117673
Li, K., Liu, Z., Hu, X., Xu, Z., Zhou, Y., Chen, L., Huang, Y., Bo, R., & Zhang, Y. (2025). Morphable 3D architectures enabled by shear-guided approach. Materials Today, 86, 28–41. https://doi.org/10.1016/j.mattod.2025.03.004
Ling, T., Ye, Y., Wang, H., Xia, C., Zhang, L., Zhao, Z., Han, M., Huang, Y., Xia, Y., Wang, D. F., Liu, X., & Wang, Z. (2025). An ultra-high sensitivity magnetic sensing mechanism with a sliding nanoelectromechanical resonator. Sensors and Actuators A: Physical, 394, 116962. https://doi.org/10.1016/j.sna.2025.116962
Malik, P., Rani, R., Gupta, R., Ameta, R. K., & Mukherjee, T. K. (2024). Recent progress on gold nanoparticle biosensors monitored water quality: Insights on diversified contaminants and functionalization paradigms. Micro and Nano Engineering, 23, 100261. https://doi.org/10.1016/j.mne.2024.100261
Moonjelly, J. J., M.K., S., Sandeep, B., C., A., V.P., M. A., K., U., Vijay, A., Radhakrishnan, E. K., & Gomes Pereira, M. de L. (2026). Chapter 4—Nanoengineering of thin film composites for tailor-made biomedical applications. In E. K. Radhakrishnan, A. Jose, & P. M. Visakh (Eds.), Nanoscale Thin Films for Biomedical Applications (pp. 89–139). Elsevier. https://doi.org/10.1016/B978-0-443-18929-6.00009-8
Naderi, A., Liu, S., Fu, J., Xu, T., Zhang, S., Ryu, J. E., & Jiang, X. (2025). Recent development in piezoelectric materials and devices for cryogenic environments. Sensors and Actuators A: Physical, 386, 116317. https://doi.org/10.1016/j.sna.2025.116317
Ning, H., Yang, L., Wang, H., & Du, Y. (2025). Ion-driven actuators based on two-dimensional nanomaterials: Microstructures, mechanisms, performance, applications, and future perspectives. Journal of Alloys and Compounds, 1042, 184192. https://doi.org/10.1016/j.jallcom.2025.184192
Okpuwhara, R. O., & Oboirien, B. O. (2025). Piezoelectric polymer nanocomposite: Fabricating methods for materials and devices. Nano Trends, 12, 100166. https://doi.org/10.1016/j.nwnano.2025.100166
Pachkawade, V. (2025). Chapter 8—Bioinspired micro-electromechanical systems/nano-electromechanical systems: An overview, applications, and perspective. In B. Hemmateenejad, Z. Altintas, & E. Rafatmah (Eds.), Nature-Derived Sensors (pp. 267–293). Elsevier. https://doi.org/10.1016/B978-0-443-22002-9.00011-7
Pal, S., & Melnik, R. (2025). Nonlocal models in biology and life sciences: Sources, developments, and applications. Physics of Life Reviews, 53, 24–75. https://doi.org/10.1016/j.plrev.2025.02.005
Petroniene, J. J., Vaiciunas, G., Garbincius, G., Dzedzickis, A., & Bucinskas, V. (2025). Sensor for cardiovascular health status monitoring: A review. Sensors and Actuators A: Physical, 392, 116720. https://doi.org/10.1016/j.sna.2025.116720
Priya, S., Sridhar, S. B., Shareef, J., Wadhwa, T., Meenakshi, D. U., & Malviya, R. (2026). Piezoelectric nanocellulose derivative for next generation cartilage biosensing: Progress in sustainable biosensing in clinical orthopaedics. Nano Biomedicine and Engineering, 18(3), 100054. https://doi.org/10.1016/j.nbe.2026.100054
Razack, R. K., Poovadichalil, N. M., & Sadasivuni, K. K. (2025). Toward autonomous medicine: A comprehensive review of biomedical energy harvesting and wearable sensing systems. Nano Energy, 145, 111422. https://doi.org/10.1016/j.nanoen.2025.111422
Revathi, S., Padmapriya, N., Padmanabhan, R., & Hashmi, M. S. J. (2024). 7.17—Nanoscale and microscale processing—Modeling. In S. Hashmi (Ed.), Comprehensive Materials Processing (Second Edition) (pp. 380–396). Elsevier. https://doi.org/10.1016/B978-0-323-96020-5.00196-5
Roshan, U., Dai, Y., Yadav, A. S., Hettiarachchi, S., Mudugamuwa, A., Zhang, J., & Nguyen, N.-T. (2025). Flexible droplet microfluidic devices for tuneable droplet generation. Sensors and Actuators B: Chemical, 422, 136617. https://doi.org/10.1016/j.snb.2024.136617
Sarkar, S., Dasgupta, U., Ghosh, M., Ganganboina, A. B., & Chowdhury, A. D. (2025). Recent advancements in dual modality biosensors for detecting disease causing pathogens. TrAC Trends in Analytical Chemistry, 193, 118454. https://doi.org/10.1016/j.trac.2025.118454
Tran, V. H. A., Lims, S. C., Anwar, N., Ahmed, M., Iram, N., Ponnusamy, V. K., & Pham, P. V. (2025). Atomic layer deposition of metal and metal oxides: Mechanisms, challenges, and future prospects. Journal of Alloys and Compounds, 1041, 183864. https://doi.org/10.1016/j.jallcom.2025.183864
Ukhurebor, K. E., Aigbe, U. O., Onyancha, R. B., Hossain, I., Emegha, J. O., & Tyokighir, S. S. (2026). A comprehensive overview of the current advancements in biosensors/Nano-biosensors. Microchemical Journal, 220, 116632. https://doi.org/10.1016/j.microc.2025.116632
Xiao, N., Tang, J., Zhou, S., Shi, Y., Qian, F., Qiu, S., Chen, Y., Zhao, D., & Yang, K. (2025). Current research on the design, properties and applications of tribological materials: A review. RSC Advances, 15(41), 34669–34717. https://doi.org/10.1039/d5ra02780b
Yadav, A. S., Vashi, A., Roshan, U., Galogahi, F. M., Tran, D. T., Sreejith, K. R., & Nguyen, N.-T. (2025). Continuous dielectrophoretic sorting of liquid beads. Sensors and Actuators B: Chemical, 435, 137627. https://doi.org/10.1016/j.snb.2025.137627
Zhao, J., Hou, H., Dang, Y., Ma, Y., Li, L., Sun, H., Sun, Z., & Xu, T. (2026). Recent advances in piezoelectric resonant infrared detectors. Infrared Physics & Technology, 152, 106155. https://doi.org/10.1016/j.infrared.2025.106155
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