PERSONALIZED NANOMEDICINE APPROACHES ENABLED BY BIOINFORMATICS AND MACHINE LEARNING
Abstract
Personalized nanomedicine has emerged as a promising approach to tailor treatments to individual patients, enhancing therapeutic efficacy while minimizing side effects. The integration of bioinformatics and machine learning (ML) has the potential to revolutionize this field by enabling more precise and efficient drug delivery systems, biomarker identification, and therapeutic strategies. However, the full potential of these technologies in personalized nanomedicine remains underexplored. This study aims to explore how bioinformatics and machine learning can enable personalized nanomedicine approaches, particularly in the areas of drug delivery optimization, patient-specific treatment planning, and biomarker discovery. The research investigates the application of these technologies in identifying individualized treatment strategies and improving patient outcomes. A systematic review of the current literature on bioinformatics, machine learning, and personalized nanomedicine was conducted. Case studies and experimental research using these technologies were analyzed to identify trends, applications, and challenges. Machine learning models were applied to bioinformatics datasets to predict drug responses and optimize nanomedicine formulations. The study found that bioinformatics and ML significantly enhance the accuracy of drug efficacy predictions, biomarker identification, and the design of personalized nanomedicine treatments. Furthermore, these technologies have improved patient-specific therapy optimization in clinical trials. The combination of bioinformatics and machine learning holds great promise for advancing personalized nanomedicine, offering tailored therapeutic solutions that improve patient outcomes and treatment efficiency.
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References
Abolhassani, H., Eskandari, A., Saremi Poor, A., Zarrabi, A., Khodadadi, B., Karimifard, S., Sahrayi, H., Bourbour, M., & Tavakkoli Yaraki, M. (2024). Nanobiotechnological approaches for breast cancer Management: Drug delivery systems and 3D In-Vitro models. Coordination Chemistry Reviews, 508, 215754. https://doi.org/10.1016/j.ccr.2024.215754
Ahmad, F., & Muhmood, T. (2024). Clinical translation of nanomedicine with integrated digital medicine and machine learning interventions. Colloids and Surfaces B: Biointerfaces, 241, 114041. https://doi.org/10.1016/j.colsurfb.2024.114041
Aja, P. M., Agu, P. C., Ogbu, C., Alum, E. U., Fasogbon, I. V., Musyoka, A. M., Ngwueche, W., Egwu, C. O., Tusubira, D., & Ross, K. (2025). RNA research for drug discovery: Recent advances and critical insight. Gene, 947, 149342. https://doi.org/10.1016/j.gene.2025.149342
Albaradei, S. (2025). AI-Driven Approaches to Utilization of Multi-Omics Data for Personalized Diagnosis and Treatment of Cancer: A Comprehensive Review. CMES - Computer Modeling in Engineering and Sciences, 145(3), 2937–2970. https://doi.org/10.32604/cmes.2025.072584
Ambreen, S., Umar, M., Noor, A., Jain, H., & Ali, R. (2025). Advanced AI and ML frameworks for transforming drug discovery and optimization: With innovative insights in polypharmacology, drug repurposing, combination therapy and nanomedicine. European Journal of Medicinal Chemistry, 284, 117164. https://doi.org/10.1016/j.ejmech.2024.117164
Azmal, M., Miah, Md. M., Prima, F. S., Paul, J. K., Haque, A. S. N. B., & Ghosh, A. (2025). Advances and challenges in cancer immunotherapy: Strategies for personalized treatment. Seminars in Oncology, 52(3), 152345. https://doi.org/10.1016/j.seminoncol.2025.152345
Chatterjee, O., Kaur, G. A., Shukla, N., Balayan, S., Singh, P. K., Chatterjee, S., & Tiwari, A. (2025). Multifaceted arsenal in SELEX nanomedicine. Advances in Colloid and Interface Science, 342, 103540. https://doi.org/10.1016/j.cis.2025.103540
Dalbanjan, N. P., Korgaonkar, K., Eelager, M. P., Gonal, B. N., Kadapure, A. J., Arakera, S. B., & Kumar S.K., P. (2025). In-silico strategies in nano-drug design: Bridging nanomaterials and pharmacological applications. Nano TransMed, 4, 100091. https://doi.org/10.1016/j.ntm.2025.100091
Dar, A. I., Randhawa, S., Verma, M., Saini, T. C., & Acharya, A. (2025). Debugging the dynamics of protein corona: Formation, composition, challenges, and applications at the nano-bio interface. Advances in Colloid and Interface Science, 342, 103535. https://doi.org/10.1016/j.cis.2025.103535
Esmaeilpour, D., Hamblin, M. R., Cheng, J., Khosravi, A., Liu, J., Zarepour, A., Zarrabi, A., Sillanpää, M., Nazarzadeh Zare, E., Shen, J., & Karimi-Maleh, H. (2026). Artificial intelligence driven protein design and sustainable nanomedicine for advanced theranostics. Bioactive Materials, 60, 425–455. https://doi.org/10.1016/j.bioactmat.2026.01.036
Gholap, A. D., & Omri, A. (2025). Advances in artificial intelligence-envisioned technologies for protein and nucleic acid research. Drug Discovery Today, 30(5), 104362. https://doi.org/10.1016/j.drudis.2025.104362
Gholap, A. D., Uddin, M. J., Faiyazuddin, M., Omri, A., Gowri, S., & Khalid, M. (2024). Advances in artificial intelligence for drug delivery and development: A comprehensive review. Computers in Biology and Medicine, 178, 108702. https://doi.org/10.1016/j.compbiomed.2024.108702
Gupta, A., Vaidya, K., & Boehnke, N. (2025). Chapter 6—AI and machine learning in pharmaceutical formulation and manufacturing of personalized medicines. In A. Pais, C. Vitorino, S. Nunes, & T. Cova (Eds.), Artificial Intelligence for Drug Product Lifecycle Applications (pp. 121–167). Academic Press. https://doi.org/10.1016/B978-0-323-91819-0.00006-3
Habeeb, M., You, H. W., Umapathi, M., Ravikumar, K. K., Hariyadi, & Mishra, S. (2024). Strategies of Artificial intelligence tools in the domain of nanomedicine. Journal of Drug Delivery Science and Technology, 91, 105157. https://doi.org/10.1016/j.jddst.2023.105157
Hafeez, S., & Maryam, S. (2026). Chapter 21—Pharmacogenomics-based nanoprecision medicine. In R. Riaz, M. Shabbir, Y. Badshah, A. Ahmad, & K. Khan (Eds.), Nanotheranostics and Precision Oncology (pp. 505–533). Academic Press. https://doi.org/10.1016/B978-0-443-34671-2.00023-2
Jin, Y., Zhou, Y., Xu, Z., Jin, Z., Meng, H., Li, S., Yan, L., Wang, H., Zheng, J.-J., Gao, X., & Zhao, Y. (2026). Silico-driven drug discovery: A paradigm shift for nanomedicine science and industry. Nano Today, 66, 102918. https://doi.org/10.1016/j.nantod.2025.102918
Karthikeyan, C., Tiwari, A., Goswami, S., Gupta, D., Joshi, M., & Mishra, D. K. (2025). Chapter 11—Future prospects of targeted drug delivery. In V. Pandey, R. Sharma, T. Haider, & D. K. Mishra (Eds.), Ligands for Targeted Drug Delivery (pp. 377–402). Academic Press. https://doi.org/10.1016/B978-0-443-33366-8.00011-7
Kaushik, H. (2026). Chapter 8—Drug discovery. In A. E. M. Eltorai, J. A. Bakal, T. Ng, F. W. Sellke, & L. A. Scrimgeour (Eds.), Translational Cardiothoracic Surgery (pp. 41–44). Academic Press. https://doi.org/10.1016/B978-0-323-90532-9.00065-0
Kawuribi, V., Xie, Y., Xu, H., Zhang, Y., & Zheng, S. (2025). Nano-omics and nanomedicine target microbial carcinogenesis: Tumor microenvironment reprograming to clinical translation. Critical Reviews in Oncology/Hematology, 213, 104866. https://doi.org/10.1016/j.critrevonc.2025.104866
Khan, M. S., Alshahrani, M. Y., Wahab, S., Gupta, G., & Kesharwani, P. (2024). Evolution of artificial intelligence as a modern technology in advanced cancer therapy. Journal of Drug Delivery Science and Technology, 98, 105892. https://doi.org/10.1016/j.jddst.2024.105892
Khorsandi, D., Farahani, A., Zarepour, A., Khosravi, A., Iravani, S., & Zarrabi, A. (2025). Bridging technology and medicine: Artificial intelligence in targeted anticancer drug delivery. RSC Advances, 15(34), 27795–27815. https://doi.org/10.1039/d5ra03747f
Le, M. H. N., Nguyen, P. K., Nguyen, T. P. T., Nguyen, H. Q., Tam, D. N. H., Huynh, H. H., Huynh, P. K., & Le, N. Q. K. (2025). An in-depth review of AI-powered advancements in cancer drug discovery. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 1871(3), 167680. https://doi.org/10.1016/j.bbadis.2025.167680
Li, F., Tang, Z., Zheng, Y., Jiang, T., Deng, L., Dai, W., Zhao, Y., Zheng, N., Liu, S., Fan, Y., Lu, S., Chen, Y., Liu, G., Zhang, Y., & Xiong, Y. (2026). Responsive nanomedicine strategies achieve pancreatic cancer precise theranostics. Bioactive Materials, 55, 334–375. https://doi.org/10.1016/j.bioactmat.2025.08.012
Liu, Y., Zhang, Y., Li, H., & Hu, T. Y. (2025). Recent advances in the bench-to-bedside translation of cancer nanomedicines. Acta Pharmaceutica Sinica B, 15(1), 97–122. https://doi.org/10.1016/j.apsb.2024.12.007
Mishra, A., Sharma, S., & Pandey, S. K. (2025). The Present State and Potential Applications of Artificial Intelligence in Cancer Diagnosis and Treatment. Recent Patents on Anti-Cancer Drug Discovery, 20(3), 287–305. https://doi.org/10.2174/0115748928361472250123105507
Mukheja, Y., Pal, K., Ahuja, A., Sarkar, A., Kumar, B., Kuhad, A., Chopra, K., & Jain, M. (2025). Nanotechnology and artificial intelligence in cancer treatment. Next Research, 2(1), 100179. https://doi.org/10.1016/j.nexres.2025.100179
Reyes, L. H., & Cruz, J. C. (2025). Chapter 1—Bioinformatic methods for the design of antimicrobial peptides. In L. H. Reyes, J. C. Cruz, & G. R. Wiedman (Eds.), Antimicrobial Peptides (pp. 3–36). Elsevier. https://doi.org/10.1016/B978-0-443-15393-8.00001-4
Shirzad, M., Salahvarzi, A., Razzaq, S., Javid-Naderi, M. J., Rahdar, A., Fathi-karkan, S., Ghadami, A., Kharaba, Z., & Romanholo Ferreira, L. F. (2025). Revolutionizing prostate cancer therapy: Artificial intelligence – Based nanocarriers for precision diagnosis and treatment. Critical Reviews in Oncology/Hematology, 208, 104653. https://doi.org/10.1016/j.critrevonc.2025.104653
Taha, B. A., Addie, A. J., Al-Rawi, M. A., Haider, A. J., Yadav, A. K., Bhatia, D., Jabir, M. S., Ibnaouf, K. H., & Arsad, N. (2025). Smart nanophotonics for enzyme-driven drug resistance sensing and controlled therapeutic release. Journal of Drug Delivery Science and Technology, 114, 107488. https://doi.org/10.1016/j.jddst.2025.107488
Taha, B. A., Addie, A. J., Chahal, S., Haider, A. J., Rustagi, S., Arsad, N., & Chaudhary, V. (2025). Unlocking new frontiers in healthcare: The impact of nano-optical biosensors on personalized medical diagnostics. Journal of Biotechnology, 400, 29–47. https://doi.org/10.1016/j.jbiotec.2025.02.005
Tarek, M., El-Gogary, R. I., & Kamel, A. O. (2025). A new era of psoriasis treatment: Drug repurposing through the lens of nanotechnology and machine learning. International Journal of Pharmaceutics, 673, 125385. https://doi.org/10.1016/j.ijpharm.2025.125385
Vengateswaran, H. T., Habeeb, M., Ahmed, R., You, H. W., Kumbhar, S. T., Chenchu Lakshmi, K. N. V., & Gorde, P. L. (2026). Integrating artificial intelligence for design, optimization and pharmacokinetic prediction in nanoparticle based drug delivery. Journal of Drug Delivery Science and Technology, 115, 107805. https://doi.org/10.1016/j.jddst.2025.107805
Weng, X., Gonzalez, M., Angelia, J., Piroozmand, S., Jamehdor, S., Behrooz, A. B., Latifi-Navid, H., Ahmadi, M., & Pecic, S. (2025). Lipidomics-driven drug discovery and delivery strategies in glioblastoma. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 1871(3), 167637. https://doi.org/10.1016/j.bbadis.2024.167637
Xu, S., Yang, H., Minev, B., & Ma, W. (2026). Biomimetic and personalized nanovaccines in cancer immunotherapy: Design innovations, translational challenges, and future directions. Journal of Advanced Research. https://doi.org/10.1016/j.jare.2026.01.070
Zahedi, A. M., Pirouzbakht, M., Zanganeh, S., & Afgar, A. (2025). Aptamer-Drug Conjugates (ApDCs): Transformative approaches in targeted cancer therapy and precision oncology. International Journal of Pharmaceutics, 681, 125902. https://doi.org/10.1016/j.ijpharm.2025.125902
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