BIOMIMETIC NANOMATERIALS FOR ADVANCED BIOMEDICAL IMPLANTATION

Aom Thai (1), Nong Chai (2), Som Chai (3)
(1) Srinakharinwirot University, Thailand,
(2) Chulalongkorn University, Thailand,
(3) Thammasat University, Thailand

Abstract

Biomimetic nanomaterials, inspired by natural systems, have gained significant attention in the field of biomedical implants due to their ability to mimic the properties of biological tissues. These materials offer advantages such as enhanced biocompatibility, improved mechanical properties, and the potential to promote tissue regeneration. The integration of biomimetic nanomaterials into biomedical implants could revolutionize the field of medical devices by improving their functionality and longevity. This study aims to explore the development and application of biomimetic nanomaterials for advanced biomedical implantation. The research focuses on evaluating their mechanical, biological, and functional properties to determine their suitability for use in medical implants. A systematic review of the latest studies on biomimetic nanomaterials for biomedical applications was conducted. Materials such as hydroxyapatite, collagen-based nanomaterials, and nanostructured metals were analyzed for their properties, performance, and potential for use in various implant types. In vitro and in vivo studies were included to assess biocompatibility and efficacy. The findings demonstrate that biomimetic nanomaterials significantly improve the performance of biomedical implants. These materials exhibit superior biocompatibility, enhanced cell adhesion, and promote better tissue integration compared to conventional materials. Biomimetic nanomaterials offer promising solutions for advanced biomedical implants. Their ability to closely mimic biological tissue properties enhances implant functionality and integration, leading to improved patient outcomes.

Full text article

Generated from XML file

References

Al-Suhaimi, E. A., Cabrera-Fuentes, H. A., AlJafary, M., Sharma, I., Kotb, E., Alharbi, G., Alyami, R., Alqarni, J., Aldossary, H. A., Jarquín González, E. E., Perez-Campos, E., & Eaissari, A. (2026). Next-generation nanotechnology strategies for infection-resistant and bio-integrative implants. Journal of Drug Delivery Science and Technology, 115, 107686. https://doi.org/10.1016/j.jddst.2025.107686

Aminnezhad, S., Hama, N. H., Hasan, A. H., Bagheri, F., & Alavi, M. (2025). Applications of biocompatible polymeric nanomaterials in three-dimensional (3D) scaffolds: Bacterial infections and diabetes. International Journal of Biological Macromolecules, 301, 140331. https://doi.org/10.1016/j.ijbiomac.2025.140331

Atia, G. A., Ali, M. A. M., Abdeen, A., Alghonemy, W. Y., Aborayah, N. H., Gebba, M. A., Amer, R. Z., Attia, S. S., Mohamed, M. E., Hetta, H. F., Abass, K. S., Chaudhary, A. A., Elfalleh, W., Bendif, H., Hussein, A. A., & El-Far, A. (2026). Halloysite nanotubes-based nanomaterials as drug carriers and scaffolds for personalized oral and maxillofacial applications. Journal of Drug Delivery Science and Technology, 119, 108141. https://doi.org/10.1016/j.jddst.2026.108141

Azizollahi, F., Oroojalian, F., Vatanchian, M., Zak, A. K., Khodabandeh, A., Moqadam, K. H., & Havakhah, S. (2026). Fabrication and characterization of a biomimetic conductive scaffold based on polycaprolactone-polyaniline/graphene oxide@naringenin silica nanoparticles to achieve enhanced bone tissue regeneration. Journal of Drug Delivery Science and Technology, 115, 107745. https://doi.org/10.1016/j.jddst.2025.107745

Bai, H., Liu, L., Luo, Z., Wan, R., & Chen, J. (2025). Advancements in two-dimensional nanomaterials for regenerative medicine in skeletal muscle repair. Materials Today Bio, 33, 101924. https://doi.org/10.1016/j.mtbio.2025.101924

Bakhshi, A., Bakhshi, M., & Naghib, S. M. (2025). Chapter 12—Light materials for bio-implants. In A. Behera & J. K. Patra (Eds.), Advanced Nanomaterials in Biomedical Implants: Processing, Structures, Properties and, Applications (pp. 307–342). Elsevier. https://doi.org/10.1016/B978-0-443-27378-0.00012-X

Bose, P., Ray, D., Sah, S. K., & Kaity, S. (2026). Implantable nanoelectronics: Material considerations and biointerface interactions. Sustainable Materials and Technologies, 47, e01837. https://doi.org/10.1016/j.susmat.2025.e01837

Cai, X.-J., Cui, Y.-Y., Ding, C.-Y., Liu, H.-B., Yu, M., Chen, L.-Y., Ding, C.-Y., Wu, X.-L., Zhang, H., Li, C., Zhang, S.-Y., Shi, X.-M., Zhang, T., Wang, C.-Y., & Liu, Y. (2026). Nanomaterial-based strategies for anti-aging and regeneration in oral and maxillofacial tissues: Mechanisms and applications. Biomaterials, 327, 123747. https://doi.org/10.1016/j.biomaterials.2025.123747

Chandan, P. B., Paul, A. R., Sahu, M. K., Kalyanasundaram, D., & Bhargava, S. K. (2026). A Critical Review on Advanced Functional Bioceramics Fabricated by SLA for Precision Implant Applications. Journal of Materials Research and Technology. https://doi.org/10.1016/j.jmrt.2026.03.188

Chauhan, N. P. S., Ashtari, B., Eftekhari, B. S., Akhshik, M., Maria, H. J., Khosravimelal, S., Seifalian, N., Thomas, S., Gholipourmalekabadi, M., & Seifalian, A. M. (2026). Functionalization of graphene oxide and its applications in tissue engineering and regenerative medicine. Biomaterials Advances, 178, 214421. https://doi.org/10.1016/j.bioadv.2025.214421

Chen, R.-L., Jiang, L., Teng, H.-B., Yang, J.-L., He, W.-B., Zhang, Y., Ren, Q., Chen, H.-X., Fan, R., & Xu, J.-G. (2026). Biomimetic nanomaterial-based strategies for spinal cord injury repair. Nano Today, 67, 102969. https://doi.org/10.1016/j.nantod.2025.102969

Chettupalli, A. K., Bukke, S. P. N., & Sharma, C. B. (2026). Cutting-edge biomaterial in implantable devices: From biocompatibility to biointegration. International Journal of Biological Macromolecules, 335, 149244. https://doi.org/10.1016/j.ijbiomac.2025.149244

Dahri, M., Rezaeian, M., Sadeghzadeh, H., Beheshtizadeh, N., Sadeghi, M. M., Zakerhamidi, D., Faraji, S. N., Pakdel, H., Dahri, B., Maleki, R., & Adibkia, K. (2025). Nanomaterial-driven macrophage polarization: Emerging strategies for immunomodulation and regenerative medicine. Biomedicine & Pharmacotherapy, 190, 118360. https://doi.org/10.1016/j.biopha.2025.118360

Dou, Y., Yin, C., Hasanirokh, K., Guo, F., Liu, J., Zhao, H., Li, G., Zhou, Q., & Wang, T. (2026). Orthopedic Applications of Inorganic Nanomaterials Particularly in Osteomyelitis. Regenesis Repair Rehabilitation. https://doi.org/10.1016/j.rerere.2026.02.003

Farzin, M. A., Naghib, S. M., & Rabiee, N. (2024). Bio-inspired and biomimetic composites based on biodegradable polymers for sensing applications with emphasis on early diagnosis of cancer. Chemical Engineering Journal, 493, 152445. https://doi.org/10.1016/j.cej.2024.152445

Golrokhian, M., Fakhimi Rezaei, H., Rezaeianjam, M., Moslem, B., Naderpour, K., & Seraji, A. A. (2025). Recent advances and clinical potential of hyaluronic acid methacrylate (HAMA)/ceramic composites in oral and dental regenerative therapies: A comprehensive review. Biomedicine & Pharmacotherapy, 192, 118590. https://doi.org/10.1016/j.biopha.2025.118590

Goshisht, M. K., Goshisht, A., Bajpai, A., & Bajpai, A. (2025). Recent advances in biomedical applications of smart nanomaterials: A comprehensive review. RSC Pharmaceutics, 2(6), 1227–1267. https://doi.org/10.1039/d5pm00137d

Gujjar, S., Kukal, S., Jayabal, P., Balaji, N., Sainger, S., Roy, S., Rallapalli, S., Mahadevappa, R., Minocha, S., Kumar, S., & Mathapati, S. (2025). Nanomaterials for biomedical applications: Addressing regulatory hurdles and strategic solutions. Nano Trends, 11, 100127. https://doi.org/10.1016/j.nwnano.2025.100127

He, W., Xu, T., Wang, M., Ni, N., Su, Y., & Fan, X. (2025). ROS-scavenging nanomaterials as emerging tools for bone tissue regeneration: A comprehensive review of recent progress. Acta Pharmaceutica Sinica B, 15(12), 6274–6306. https://doi.org/10.1016/j.apsb.2025.09.040

Hossain, A., Shuvo, M. R. H., Khan, S., Sayem, A. S. M., Islam, S., & Hossain, N. (2025). Functional nanoparticle developments for 3D-printed biodegradable implants- A comprehensive review. Results in Surfaces and Interfaces, 19, 100541. https://doi.org/10.1016/j.rsurfi.2025.100541

Kangarshahi, B. M., & Naghib, S. M. (2026). 19—Polyurethane nanocomposites for tissue engineering and regenerative medicine applications. In K. Deshmukh & M. Pandey (Eds.), Polyurethane Nanocomposites (pp. 815–866). Woodhead Publishing. https://doi.org/10.1016/B978-0-443-29904-9.00022-0

Kashyap, V., Sarkar, M., Singh, N., Singh, A., Verma, D., Bhatia, D., & Yadav, A. K. (2026). From nature to engineering: Translational progress in biological, biomimetic, and bioinspired nanomaterials for next-generation technologies. Progress in Materials Science, 160, 101684. https://doi.org/10.1016/j.pmatsci.2026.101684

Lee, H., Kim, K. S., Zare, I., Bang, S., Kang, H. S., Moon, C. H., Gwon, J. Y., Seo, J. H., Joo, H., Cho, Y., Jung, H., Rha, H., Lee, D. Y., Yang, K., Lim, D., Lee, S.-H., Cha, G. D., Na, K., Kang, M.-H., … Jung, H.-D. (2025). Smart nanomaterials for multimodal theranostics and tissue regeneration. Coordination Chemistry Reviews, 541, 216801. https://doi.org/10.1016/j.ccr.2025.216801

Li, X., Lv, H., Mou, Y., Xiu, W., Han, L., Chu, Z., & Dong, H. (2026). Engineering biomedical membranes for guided bone regeneration. Advanced Membranes, 7, 100215. https://doi.org/10.1016/j.advmem.2026.100215

Lin, C., Huang, X., Xue, Y., Jiang, S., Chen, C., Liu, Y., & Chen, K. (2025). Advances in medical devices using nanomaterials and nanotechnology: Innovation and regulatory science. Bioactive Materials, 48, 353–369. https://doi.org/10.1016/j.bioactmat.2025.02.017

Lin, H., Zhou, C., Li, Q., Xie, Q., Xia, L., Liu, L., Bao, W., Xiong, X., Zhang, H., Zheng, Z., Zhao, J., & Liang, W. (2025). Nanotechnology-Assisted mesenchymal stem cells treatment for improved cartilage regeneration: A review of current practices. Biochemical Pharmacology, 237, 116895. https://doi.org/10.1016/j.bcp.2025.116895

Ma, H., Su, X., Liang, J., Liu, L., Sun, J., Tong, J., Lu, J., Zhang, Y., Lei, B., & Zhao, H. (2025). Bioactive protein/polysaccharide hydrogel functionalized bone implants surface for enhanced osteogenesis. International Journal of Biological Macromolecules, 317, 144626. https://doi.org/10.1016/j.ijbiomac.2025.144626

Mullick, P., & Manna, A. (2025). Nano-biomaterials: Emerging tools in biomedical innovation and therapy. Current Opinion in Biomedical Engineering, 36, 100627. https://doi.org/10.1016/j.cobme.2025.100627

Mundekkad, D., & Mallya, A. R. (2025). Biomimicry at the nanoscale—A review of nanomaterials inspired by nature. Nano Trends, 10, 100119. https://doi.org/10.1016/j.nwnano.2025.100119

Nagaraj, K., Anbazhagan, G. K., Govindasamy, R. S., Muthu, V., Rajkumar, S., Senthilnathan, S., Muddana, S., Esanakula, R. R., Sivakumar, D., Deepa Harini Sri, C., Mujibur Rahman, M. fayaz lathief, Ravi, R., Senthil Murugan, M., & Rajendren, G. (2025). Biomimetic surfactants for tunable interfacial properties in drug delivery, biomedical coatings and tissue engineering. International Journal of Pharmaceutics, 677, 125658. https://doi.org/10.1016/j.ijpharm.2025.125658

Nasri, N., Azad, M., Mehrabi, Z., Dini, G., & Marandi, A. (2025). Metal–organic frameworks for biomedical applications: Bridging materials science and regenerative medicine. RSC Advances, 15(41), 34481–34509. https://doi.org/10.1039/d5ra05337d

Patra, P., Verma, A., Srivastava, R., Murugaiyan, K., & Rengan, A. K. (2025). 16—Biomimetic nanohydrogels in tissue engineering and regenerative medicine. In R. Jayakumar & A. K. Rajendran (Eds.), Hydrogel Tissue Analogues (pp. 459–501). Woodhead Publishing. https://doi.org/10.1016/B978-0-443-29260-6.00010-X

Pavithra, B., Singh, P., Kumar, V. R., Durairaj, S., & Hassan, S. (2025). Advances in polymeric nanoparticles and hydrogels in 3D bioprinting: Enhancing bioinks for tissue engineering and regenerative medicine. Bioprinting, 51, e00438. https://doi.org/10.1016/j.bprint.2025.e00438

Razzaq, M. H., Zaheer, M. U., Asghar, H., Aktas, O. C., Aycan, M. F., & Mishra, Y. K. (2025). Additive manufacturing for biomedical bone implants: Shaping the future of bones. Materials Science and Engineering: R: Reports, 163, 100931. https://doi.org/10.1016/j.mser.2025.100931

Saha, H., Halder, J., Rizmi, R. K. B. M., Hossain, S., Alam, M., Azad, H. K. M., & Rahman, M. Z. (2024). 7.12—Recent advancements in nanostructured biomaterials for biomedical applications and regenerative medicine. In S. Hashmi (Ed.), Comprehensive Materials Processing (Second Edition) (pp. 255–275). Elsevier. https://doi.org/10.1016/B978-0-323-96020-5.00283-1

Authors

Aom Thai
aomthaii@gmail.com (Primary Contact)
Nong Chai
Som Chai
Thai, A., Chai, N. ., & Chai, S. . (2026). BIOMIMETIC NANOMATERIALS FOR ADVANCED BIOMEDICAL IMPLANTATION. Journal of Biomedical and Techno Nanomaterials, 3(1), 50–61. https://doi.org/10.70177/jbtn.v3i1.3560

Article Details