BIOMIMETIC NANOMATERIALS FOR ADVANCED BIOMEDICAL IMPLANTATION
Abstract
Biomimetic nanomaterials, inspired by natural systems, have gained significant attention in the field of biomedical implants due to their ability to mimic the properties of biological tissues. These materials offer advantages such as enhanced biocompatibility, improved mechanical properties, and the potential to promote tissue regeneration. The integration of biomimetic nanomaterials into biomedical implants could revolutionize the field of medical devices by improving their functionality and longevity. This study aims to explore the development and application of biomimetic nanomaterials for advanced biomedical implantation. The research focuses on evaluating their mechanical, biological, and functional properties to determine their suitability for use in medical implants. A systematic review of the latest studies on biomimetic nanomaterials for biomedical applications was conducted. Materials such as hydroxyapatite, collagen-based nanomaterials, and nanostructured metals were analyzed for their properties, performance, and potential for use in various implant types. In vitro and in vivo studies were included to assess biocompatibility and efficacy. The findings demonstrate that biomimetic nanomaterials significantly improve the performance of biomedical implants. These materials exhibit superior biocompatibility, enhanced cell adhesion, and promote better tissue integration compared to conventional materials. Biomimetic nanomaterials offer promising solutions for advanced biomedical implants. Their ability to closely mimic biological tissue properties enhances implant functionality and integration, leading to improved patient outcomes.
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References
Al-Suhaimi, E. A., Cabrera-Fuentes, H. A., AlJafary, M., Sharma, I., Kotb, E., Alharbi, G., Alyami, R., Alqarni, J., Aldossary, H. A., Jarquín González, E. E., Perez-Campos, E., & Eaissari, A. (2026). Next-generation nanotechnology strategies for infection-resistant and bio-integrative implants. Journal of Drug Delivery Science and Technology, 115, 107686. https://doi.org/10.1016/j.jddst.2025.107686
Aminnezhad, S., Hama, N. H., Hasan, A. H., Bagheri, F., & Alavi, M. (2025). Applications of biocompatible polymeric nanomaterials in three-dimensional (3D) scaffolds: Bacterial infections and diabetes. International Journal of Biological Macromolecules, 301, 140331. https://doi.org/10.1016/j.ijbiomac.2025.140331
Atia, G. A., Ali, M. A. M., Abdeen, A., Alghonemy, W. Y., Aborayah, N. H., Gebba, M. A., Amer, R. Z., Attia, S. S., Mohamed, M. E., Hetta, H. F., Abass, K. S., Chaudhary, A. A., Elfalleh, W., Bendif, H., Hussein, A. A., & El-Far, A. (2026). Halloysite nanotubes-based nanomaterials as drug carriers and scaffolds for personalized oral and maxillofacial applications. Journal of Drug Delivery Science and Technology, 119, 108141. https://doi.org/10.1016/j.jddst.2026.108141
Azizollahi, F., Oroojalian, F., Vatanchian, M., Zak, A. K., Khodabandeh, A., Moqadam, K. H., & Havakhah, S. (2026). Fabrication and characterization of a biomimetic conductive scaffold based on polycaprolactone-polyaniline/graphene oxide@naringenin silica nanoparticles to achieve enhanced bone tissue regeneration. Journal of Drug Delivery Science and Technology, 115, 107745. https://doi.org/10.1016/j.jddst.2025.107745
Bai, H., Liu, L., Luo, Z., Wan, R., & Chen, J. (2025). Advancements in two-dimensional nanomaterials for regenerative medicine in skeletal muscle repair. Materials Today Bio, 33, 101924. https://doi.org/10.1016/j.mtbio.2025.101924
Bakhshi, A., Bakhshi, M., & Naghib, S. M. (2025). Chapter 12—Light materials for bio-implants. In A. Behera & J. K. Patra (Eds.), Advanced Nanomaterials in Biomedical Implants: Processing, Structures, Properties and, Applications (pp. 307–342). Elsevier. https://doi.org/10.1016/B978-0-443-27378-0.00012-X
Bose, P., Ray, D., Sah, S. K., & Kaity, S. (2026). Implantable nanoelectronics: Material considerations and biointerface interactions. Sustainable Materials and Technologies, 47, e01837. https://doi.org/10.1016/j.susmat.2025.e01837
Cai, X.-J., Cui, Y.-Y., Ding, C.-Y., Liu, H.-B., Yu, M., Chen, L.-Y., Ding, C.-Y., Wu, X.-L., Zhang, H., Li, C., Zhang, S.-Y., Shi, X.-M., Zhang, T., Wang, C.-Y., & Liu, Y. (2026). Nanomaterial-based strategies for anti-aging and regeneration in oral and maxillofacial tissues: Mechanisms and applications. Biomaterials, 327, 123747. https://doi.org/10.1016/j.biomaterials.2025.123747
Chandan, P. B., Paul, A. R., Sahu, M. K., Kalyanasundaram, D., & Bhargava, S. K. (2026). A Critical Review on Advanced Functional Bioceramics Fabricated by SLA for Precision Implant Applications. Journal of Materials Research and Technology. https://doi.org/10.1016/j.jmrt.2026.03.188
Chauhan, N. P. S., Ashtari, B., Eftekhari, B. S., Akhshik, M., Maria, H. J., Khosravimelal, S., Seifalian, N., Thomas, S., Gholipourmalekabadi, M., & Seifalian, A. M. (2026). Functionalization of graphene oxide and its applications in tissue engineering and regenerative medicine. Biomaterials Advances, 178, 214421. https://doi.org/10.1016/j.bioadv.2025.214421
Chen, R.-L., Jiang, L., Teng, H.-B., Yang, J.-L., He, W.-B., Zhang, Y., Ren, Q., Chen, H.-X., Fan, R., & Xu, J.-G. (2026). Biomimetic nanomaterial-based strategies for spinal cord injury repair. Nano Today, 67, 102969. https://doi.org/10.1016/j.nantod.2025.102969
Chettupalli, A. K., Bukke, S. P. N., & Sharma, C. B. (2026). Cutting-edge biomaterial in implantable devices: From biocompatibility to biointegration. International Journal of Biological Macromolecules, 335, 149244. https://doi.org/10.1016/j.ijbiomac.2025.149244
Dahri, M., Rezaeian, M., Sadeghzadeh, H., Beheshtizadeh, N., Sadeghi, M. M., Zakerhamidi, D., Faraji, S. N., Pakdel, H., Dahri, B., Maleki, R., & Adibkia, K. (2025). Nanomaterial-driven macrophage polarization: Emerging strategies for immunomodulation and regenerative medicine. Biomedicine & Pharmacotherapy, 190, 118360. https://doi.org/10.1016/j.biopha.2025.118360
Dou, Y., Yin, C., Hasanirokh, K., Guo, F., Liu, J., Zhao, H., Li, G., Zhou, Q., & Wang, T. (2026). Orthopedic Applications of Inorganic Nanomaterials Particularly in Osteomyelitis. Regenesis Repair Rehabilitation. https://doi.org/10.1016/j.rerere.2026.02.003
Farzin, M. A., Naghib, S. M., & Rabiee, N. (2024). Bio-inspired and biomimetic composites based on biodegradable polymers for sensing applications with emphasis on early diagnosis of cancer. Chemical Engineering Journal, 493, 152445. https://doi.org/10.1016/j.cej.2024.152445
Golrokhian, M., Fakhimi Rezaei, H., Rezaeianjam, M., Moslem, B., Naderpour, K., & Seraji, A. A. (2025). Recent advances and clinical potential of hyaluronic acid methacrylate (HAMA)/ceramic composites in oral and dental regenerative therapies: A comprehensive review. Biomedicine & Pharmacotherapy, 192, 118590. https://doi.org/10.1016/j.biopha.2025.118590
Goshisht, M. K., Goshisht, A., Bajpai, A., & Bajpai, A. (2025). Recent advances in biomedical applications of smart nanomaterials: A comprehensive review. RSC Pharmaceutics, 2(6), 1227–1267. https://doi.org/10.1039/d5pm00137d
Gujjar, S., Kukal, S., Jayabal, P., Balaji, N., Sainger, S., Roy, S., Rallapalli, S., Mahadevappa, R., Minocha, S., Kumar, S., & Mathapati, S. (2025). Nanomaterials for biomedical applications: Addressing regulatory hurdles and strategic solutions. Nano Trends, 11, 100127. https://doi.org/10.1016/j.nwnano.2025.100127
He, W., Xu, T., Wang, M., Ni, N., Su, Y., & Fan, X. (2025). ROS-scavenging nanomaterials as emerging tools for bone tissue regeneration: A comprehensive review of recent progress. Acta Pharmaceutica Sinica B, 15(12), 6274–6306. https://doi.org/10.1016/j.apsb.2025.09.040
Hossain, A., Shuvo, M. R. H., Khan, S., Sayem, A. S. M., Islam, S., & Hossain, N. (2025). Functional nanoparticle developments for 3D-printed biodegradable implants- A comprehensive review. Results in Surfaces and Interfaces, 19, 100541. https://doi.org/10.1016/j.rsurfi.2025.100541
Kangarshahi, B. M., & Naghib, S. M. (2026). 19—Polyurethane nanocomposites for tissue engineering and regenerative medicine applications. In K. Deshmukh & M. Pandey (Eds.), Polyurethane Nanocomposites (pp. 815–866). Woodhead Publishing. https://doi.org/10.1016/B978-0-443-29904-9.00022-0
Kashyap, V., Sarkar, M., Singh, N., Singh, A., Verma, D., Bhatia, D., & Yadav, A. K. (2026). From nature to engineering: Translational progress in biological, biomimetic, and bioinspired nanomaterials for next-generation technologies. Progress in Materials Science, 160, 101684. https://doi.org/10.1016/j.pmatsci.2026.101684
Lee, H., Kim, K. S., Zare, I., Bang, S., Kang, H. S., Moon, C. H., Gwon, J. Y., Seo, J. H., Joo, H., Cho, Y., Jung, H., Rha, H., Lee, D. Y., Yang, K., Lim, D., Lee, S.-H., Cha, G. D., Na, K., Kang, M.-H., … Jung, H.-D. (2025). Smart nanomaterials for multimodal theranostics and tissue regeneration. Coordination Chemistry Reviews, 541, 216801. https://doi.org/10.1016/j.ccr.2025.216801
Li, X., Lv, H., Mou, Y., Xiu, W., Han, L., Chu, Z., & Dong, H. (2026). Engineering biomedical membranes for guided bone regeneration. Advanced Membranes, 7, 100215. https://doi.org/10.1016/j.advmem.2026.100215
Lin, C., Huang, X., Xue, Y., Jiang, S., Chen, C., Liu, Y., & Chen, K. (2025). Advances in medical devices using nanomaterials and nanotechnology: Innovation and regulatory science. Bioactive Materials, 48, 353–369. https://doi.org/10.1016/j.bioactmat.2025.02.017
Lin, H., Zhou, C., Li, Q., Xie, Q., Xia, L., Liu, L., Bao, W., Xiong, X., Zhang, H., Zheng, Z., Zhao, J., & Liang, W. (2025). Nanotechnology-Assisted mesenchymal stem cells treatment for improved cartilage regeneration: A review of current practices. Biochemical Pharmacology, 237, 116895. https://doi.org/10.1016/j.bcp.2025.116895
Ma, H., Su, X., Liang, J., Liu, L., Sun, J., Tong, J., Lu, J., Zhang, Y., Lei, B., & Zhao, H. (2025). Bioactive protein/polysaccharide hydrogel functionalized bone implants surface for enhanced osteogenesis. International Journal of Biological Macromolecules, 317, 144626. https://doi.org/10.1016/j.ijbiomac.2025.144626
Mullick, P., & Manna, A. (2025). Nano-biomaterials: Emerging tools in biomedical innovation and therapy. Current Opinion in Biomedical Engineering, 36, 100627. https://doi.org/10.1016/j.cobme.2025.100627
Mundekkad, D., & Mallya, A. R. (2025). Biomimicry at the nanoscale—A review of nanomaterials inspired by nature. Nano Trends, 10, 100119. https://doi.org/10.1016/j.nwnano.2025.100119
Nagaraj, K., Anbazhagan, G. K., Govindasamy, R. S., Muthu, V., Rajkumar, S., Senthilnathan, S., Muddana, S., Esanakula, R. R., Sivakumar, D., Deepa Harini Sri, C., Mujibur Rahman, M. fayaz lathief, Ravi, R., Senthil Murugan, M., & Rajendren, G. (2025). Biomimetic surfactants for tunable interfacial properties in drug delivery, biomedical coatings and tissue engineering. International Journal of Pharmaceutics, 677, 125658. https://doi.org/10.1016/j.ijpharm.2025.125658
Nasri, N., Azad, M., Mehrabi, Z., Dini, G., & Marandi, A. (2025). Metal–organic frameworks for biomedical applications: Bridging materials science and regenerative medicine. RSC Advances, 15(41), 34481–34509. https://doi.org/10.1039/d5ra05337d
Patra, P., Verma, A., Srivastava, R., Murugaiyan, K., & Rengan, A. K. (2025). 16—Biomimetic nanohydrogels in tissue engineering and regenerative medicine. In R. Jayakumar & A. K. Rajendran (Eds.), Hydrogel Tissue Analogues (pp. 459–501). Woodhead Publishing. https://doi.org/10.1016/B978-0-443-29260-6.00010-X
Pavithra, B., Singh, P., Kumar, V. R., Durairaj, S., & Hassan, S. (2025). Advances in polymeric nanoparticles and hydrogels in 3D bioprinting: Enhancing bioinks for tissue engineering and regenerative medicine. Bioprinting, 51, e00438. https://doi.org/10.1016/j.bprint.2025.e00438
Razzaq, M. H., Zaheer, M. U., Asghar, H., Aktas, O. C., Aycan, M. F., & Mishra, Y. K. (2025). Additive manufacturing for biomedical bone implants: Shaping the future of bones. Materials Science and Engineering: R: Reports, 163, 100931. https://doi.org/10.1016/j.mser.2025.100931
Saha, H., Halder, J., Rizmi, R. K. B. M., Hossain, S., Alam, M., Azad, H. K. M., & Rahman, M. Z. (2024). 7.12—Recent advancements in nanostructured biomaterials for biomedical applications and regenerative medicine. In S. Hashmi (Ed.), Comprehensive Materials Processing (Second Edition) (pp. 255–275). Elsevier. https://doi.org/10.1016/B978-0-323-96020-5.00283-1
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