Journal of Biomedical and Techno Nanomaterials

PHARMACEUTICAL NANOTECHNOLOGY FOR IMPROVING BIOAVAILABILITY AND THERAPEUTIC EFFICACY

Fatima Ahmed — 2026-04-04

Pharmaceutical nanotechnology has emerged as a promising approach to enhance the bioavailability and therapeutic efficacy of drugs. Many drugs suffer from poor solubility, limited absorption, and rapid metabolism, leading to suboptimal therapeutic outcomes. Nanotechnology-based drug delivery systems offer solutions to these challenges by improving the stability, solubility, and controlled release of pharmaceuticals. This study explores the use of nanotechnology in the design and development of drug delivery systems aimed at enhancing bioavailability and optimizing therapeutic efficacy. The primary objective is to evaluate the effectiveness of various nanocarriers, including liposomes, dendrimers, and polymeric nanoparticles, in improving drug solubility and ensuring targeted delivery. The research employs in vitro and in vivo models to assess drug release profiles, absorption rates, and pharmacokinetic properties. The results demonstrate that nanotechnology-based systems significantly improve drug bioavailability and extend therapeutic efficacy by providing controlled and sustained drug release, reducing side effects, and enhancing cellular uptake. In conclusion, pharmaceutical nanotechnology offers a powerful strategy to overcome the limitations of conventional drug delivery systems, providing a pathway for more effective treatments in various therapeutic areas.

ADVANCED NANOCARRIERS FOR CONTROLLED DRUG AND GENE DELIVERY IN CHRONIC DISEASES

Ren Suzuki — 2026-04-19

Chronic diseases such as cancer, cardiovascular diseases, and neurodegenerative disorders pose significant treatment challenges due to their complexity and resistance to conventional therapies. Nanocarriers, as advanced drug and gene delivery systems, offer a promising solution to address these challenges by providing controlled release, improved targeting, and enhanced therapeutic efficacy. The ability to design nanocarriers that are biocompatible, stable, and capable of precise targeting to diseased tissues holds potential for revolutionizing the treatment of chronic diseases. This study aims to explore the design, development, and evaluation of advanced nanocarriers for controlled drug and gene delivery in chronic diseases. The research focuses on evaluating the efficacy of various nanocarriers, including liposomes, dendrimers, and nanoparticles, in improving drug bioavailability, targeting precision, and therapeutic outcomes in chronic disease models. The research utilizes in vitro cell culture studies and in vivo animal models to assess the effectiveness of different nanocarriers. Characterization techniques, including dynamic light scattering (DLS), transmission electron microscopy (TEM), and drug release assays, are used to evaluate the properties and performance of the nanocarriers. The study demonstrates that advanced nanocarriers significantly improve drug delivery efficiency, reduce systemic toxicity, and enhance therapeutic outcomes in chronic disease models. Gene delivery using nanocarriers also shows promising results in terms of targeted therapy. Advanced nanocarriers are a promising tool for controlled drug and gene delivery, offering potential breakthroughs in the treatment of chronic diseases by improving precision and minimizing side effects.

BIODEGRADABLE NANOMATERIALS FOR TISSUE ENGINEERING AND REGENERATIVE MEDICINE APPLICATIONS

Fitriani Fitriani — 2026-04-22

The field of tissue engineering and regenerative medicine has seen significant advancements with the use of nanomaterials, particularly biodegradable nanomaterials, which offer promising solutions for tissue regeneration and repair. These materials, due to their biocompatibility, biodegradability, and ability to mimic the extracellular matrix, play a crucial role in supporting cell growth, tissue development, and healing processes. Despite these promising properties, challenges remain regarding the optimization of nanomaterial performance, including controlled degradation rates and tissue-specific responses. This study aims to explore the potential of biodegradable nanomaterials in tissue engineering and regenerative medicine, focusing on their applications, properties, and functional enhancements through design optimization. The research aims to evaluate the efficacy of these nanomaterials in promoting tissue regeneration in various models, including bone, cartilage, and soft tissues. The study involves the synthesis and characterization of biodegradable nanomaterials, including nanofibers, nanoparticles, and hydrogels. In vitro cell culture assays and in vivo animal models are used to assess cell viability, proliferation, differentiation, and tissue regeneration potential. The study demonstrates that biodegradable nanomaterials significantly promote cell proliferation and differentiation, accelerating tissue repair and regeneration in all tested models. Controlled degradation rates of the nanomaterials contributed to sustained cell support and tissue integration. Biodegradable nanomaterials hold substantial promise for advancing tissue engineering and regenerative medicine, offering effective and sustainable solutions for tissue repair and regeneration.