SOCIAL ISOLATION AND COGNITIVE DECLINE IN AGING POPULATIONS: AI-POWERED MONITORING SYSTEMS FOR EARLY DETECTION
Abstract
Social isolation is a significant and modifiable risk factor for accelerated cognitive decline and dementia in aging populations. Traditional methods for detecting cognitive changes, such as clinical screenings, are often infrequent and fail to capture the subtle, early behavioral shifts that precede a formal diagnosis. This study aimed to develop and validate an artificial intelligence model designed for the early detection of cognitive decline by passively monitoring behavioral and vocal biomarkers of social isolation in older adults living independently. A 24-month, prospective longitudinal study was conducted with a cohort of 200 community-dwelling adults aged 70 and older. A suite of unobtrusive in-home sensors was used to passively collect data on movement patterns, social communication (frequency and duration of conversations), and computer/phone usage. The AI-powered system identified individuals who would later show clinically significant cognitive decline with an accuracy of 91% and a lead time of approximately 7 months before formal assessment. Decreased frequency of vocal interactions and increased irregularity in daily routines were the most powerful predictors. AI-powered passive monitoring systems are a highly effective and ecologically valid tool for the pre-clinical detection of cognitive decline linked to social isolation.
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References
Abd-Alrazaq, A. (2024). Detection of Sleep Apnea Using Wearable AI: Systematic Review and Meta-Analysis. Journal of Medical Internet Research, 26(Query date: 2026-03-26 14:10:35). https://doi.org/10.2196/58187
Ahmad, I. (2024). Autism spectrum disorder detection using facial images: A performance comparison of pretrained convolutional neural networks. Healthcare Technology Letters, 11(4), 227–239. https://doi.org/10.1049/htl2.12073
Ahmed, M. M. (2024). Brain tumor detection and classification in MRI using hybrid ViT and GRU model with explainable AI in Southern Bangladesh. Scientific Reports, 14(1). https://doi.org/10.1038/s41598-024-71893-3
Akhyar, A. (2024). Deep artificial intelligence applications for natural disaster management systems: A methodological review. Ecological Indicators, 163(Query date: 2026-03-26 14:10:35). https://doi.org/10.1016/j.ecolind.2024.112067
Alavee, K. A. (2024). Enhancing Early Detection of Diabetic Retinopathy Through the Integration of Deep Learning Models and Explainable Artificial Intelligence. IEEE Access, 12(Query date: 2026-03-26 14:10:35), 73950–73969. https://doi.org/10.1109/ACCESS.2024.3405570
Alnaggar, O. A. M. F. (2024). Efficient artificial intelligence approaches for medical image processing in healthcare: Comprehensive review, taxonomy, and analysis. Artificial Intelligence Review, 57(8). https://doi.org/10.1007/s10462-024-10814-2
Bohara, K. (2024). Emerging technologies revolutionising disease diagnosis and monitoring in aquatic animal health. Reviews in Aquaculture, 16(2), 836–854. https://doi.org/10.1111/raq.12870
Chan, Y. T. (2024). Biomarkers for diagnosis and therapeutic options in hepatocellular carcinoma. Molecular Cancer, 23(1). https://doi.org/10.1186/s12943-024-02101-z
Chugh, V. (2024). Employing nano-enabled artificial intelligence (AI)-based smart technologies for prediction, screening, and detection of cancer. Nanoscale, 16(11), 5458–5486. https://doi.org/10.1039/d3nr05648a
DeGroat, W. (2024). Discovering biomarkers associated and predicting cardiovascular disease with high accuracy using a novel nexus of machine learning techniques for precision medicine. Scientific Reports, 14(1). https://doi.org/10.1038/s41598-023-50600-8
Eleyan, A. (2024). Electrocardiogram Signals Classification Using Deep-Learning-Based Incorporated Convolutional Neural Network and Long Short-Term Memory Framework †. Computers, 13(2). https://doi.org/10.3390/computers13020055
Elsheikh, S. (2024). Atrial fibrillation and stroke: State-of-the-art and future directions. Current Problems in Cardiology, 49(1). https://doi.org/10.1016/j.cpcardiol.2023.102181
Elyoseph, Z. (2024). Capacity of Generative AI to Interpret Human Emotions From Visual and Textual Data: Pilot Evaluation Study. Jmir Mental Health, 11(1). https://doi.org/10.2196/54369
González-Rodríguez, V. E. (2024). Artificial Intelligence: A Promising Tool for Application in Phytopathology. Horticulturae, 10(3). https://doi.org/10.3390/horticulturae10030197
Guebsi, R. (2024). Drones in Precision Agriculture: A Comprehensive Review of Applications, Technologies, and Challenges. Drones, 8(11). https://doi.org/10.3390/drones8110686
He, K. (2024). Decoding the glycoproteome: A new frontier for biomarker discovery in cancer. Journal of Hematology and Oncology, 17(1). https://doi.org/10.1186/s13045-024-01532-x
Hong, S. (2025). Biomaterials for reliable wearable health monitoring: Applications in skin and eye integration. Biomaterials, 314(Query date: 2026-03-26 14:10:35). https://doi.org/10.1016/j.biomaterials.2024.122862
Islam, S. I. (2024). Cutting-edge technologies for detecting and controlling fish diseases: Current status, outlook, and challenges. Journal of the World Aquaculture Society, 55(2). https://doi.org/10.1111/jwas.13051
Joshi, A. A. (2024). Deep learning approach for brain tumor classification using metaheuristic optimization with gene expression data. International Journal of Imaging Systems and Technology, 34(2). https://doi.org/10.1002/ima.23007
Khaliki, M. Z. (2024). Brain tumor detection from images and comparison with transfer learning methods and 3-layer CNN. Scientific Reports, 14(1). https://doi.org/10.1038/s41598-024-52823-9
Khan, M. F. (2024). Brain Tumor Segmentation and Classification using Optimized Deep Learning. Journal of Computing and Biomedical Informatics, 7(1). https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=105026818389&origin=inward
Khan, T., Khan, U., Khan, A., Mollan, C., Morkvenaite-Vilkonciene, I., & Pandey, V. (2025). Data-Driven Digital Twin Framework for Predictive Maintenance of Smart Manufacturing Systems. Machines, 13(6). Scopus. https://doi.org/10.3390/machines13060481
Lam, S. (2024). Current and Future Perspectives on Computed Tomography Screening for Lung Cancer: A Roadmap From 2023 to 2027 From the International Association for the Study of Lung Cancer. Journal of Thoracic Oncology, 19(1), 36–51. https://doi.org/10.1016/j.jtho.2023.07.019
Lauritzen, A. D. (2024). Early Indicators of the Impact of Using AI in Mammography Screening for Breast Cancer. Radiology, 311(3). https://doi.org/10.1148/radiol.232479
Liao, H. (2024). Climate change, its impact on emerging infectious diseases and new technologies to combat the challenge. Emerging Microbes and Infections, 13(1). https://doi.org/10.1080/22221751.2024.2356143
Lim, D. Y. Z. (2024). ChatGPT on guidelines: Providing contextual knowledge to GPT allows it to provide advice on appropriate colonoscopy intervals. Journal of Gastroenterology and Hepatology Australia, 39(1), 81–106. https://doi.org/10.1111/jgh.16375
Mahmoud, N. M. (2024). Early automated detection system for skin cancer diagnosis using artificial intelligent techniques. Scientific Reports, 14(1). https://doi.org/10.1038/s41598-024-59783-0
Markandan, K. (2024). Emergence of infectious diseases and role of advanced nanomaterials in point-of-care diagnostics: A review. Biotechnology and Genetic Engineering Reviews, 40(4), 3438–3526. https://doi.org/10.1080/02648725.2022.2127070
Mira, E. S. (2024). Early Diagnosis of Oral Cancer Using Image Processing and Artificial Intelligence. Fusion Practice and Applications, 14(1), 293–308. https://doi.org/10.54216/FPA.140122
Narotamo, H. (2024). Deep learning for ECG classification: A comparative study of 1D and 2D representations and multimodal fusion approaches. Biomedical Signal Processing and Control, 93(Query date: 2026-03-26 14:10:35). https://doi.org/10.1016/j.bspc.2024.106141
Nashruddin, S. N. A. B. M. (2024). Artificial intelligence?powered electrochemical sensor: Recent advances, challenges, and prospects. Heliyon, 10(18). https://doi.org/10.1016/j.heliyon.2024.e37964
Oh, S. (2024). Bioelectronic Implantable Devices for Physiological Signal Recording and Closed-Loop Neuromodulation. Advanced Functional Materials, 34(41). https://doi.org/10.1002/adfm.202403562
Ouanes, K. (2024). Effectiveness of Artificial Intelligence (AI) in Clinical Decision Support Systems and Care Delivery. Journal of Medical Systems, 48(1). https://doi.org/10.1007/s10916-024-02098-4
Park, Y. J. (2025). Convolutional LSTM Neural Network Autoencoder Based Fault Detection in Manufacturing Predictive Maintenance. Journal of Machine and Computing, 5(2), 914–923. Scopus. https://doi.org/10.53759/7669/jmc202505072
Peixoto, T., Oliveira, B., Oliveira, Ó., & Ribeiro, F. (2025). Data Quality Assessment in Smart Manufacturing: A Review. Systems, 13(4). Scopus. https://doi.org/10.3390/systems13040243
Qiao, D. (2024). Data-Driven Fault Diagnosis of Internal Short Circuit for Series-Connected Battery Packs Using Partial Voltage Curves. IEEE Transactions on Industrial Informatics, 20(4), 6751–6761. https://doi.org/10.1109/TII.2024.3353872
Romero-Oraá, R. (2024). Attention-based deep learning framework for automatic fundus image processing to aid in diabetic retinopathy grading. Computer Methods and Programs in Biomedicine, 249(Query date: 2026-03-26 14:10:35). https://doi.org/10.1016/j.cmpb.2024.108160
Shamta, I. (2024). Development of a deep learning-based surveillance system for forest fire detection and monitoring using UAV. Plos One, 19(3). https://doi.org/10.1371/journal.pone.0299058
Simhadri, C. G. (2025). Deep learning for rice leaf disease detection: A systematic literature review on emerging trends, methodologies and techniques. Information Processing in Agriculture, 12(2), 151–168. https://doi.org/10.1016/j.inpa.2024.04.006
Sivakumar, M., Maranco, M., Krishnaraj, N., & Srinivasulu Reddy, U. (2025). Data Analytics and Visualization in Smart Manufacturing Using AI-Based Digital Twins. In Artificial Intelligence-Enabled Digital Twin for Smart Manufacturing (pp. 249–277). wiley. Scopus. https://doi.org/10.1002/9781394303601.ch12
Tenchov, R. (2024). Biomarkers for Early Cancer Detection: A Landscape View of Recent Advancements, Spotlighting Pancreatic and Liver Cancers. ACS Pharmacology and Translational Science, 7(3), 586–613. https://doi.org/10.1021/acsptsci.3c00346
Tiwari, A. (2025). Current AI technologies in cancer diagnostics and treatment. Molecular Cancer, 24(1). https://doi.org/10.1186/s12943-025-02369-9
Wolf, R. M. (2024). Autonomous artificial intelligence increases screening and follow-up for diabetic retinopathy in youth: The ACCESS randomized control trial. Nature Communications, 15(1). https://doi.org/10.1038/s41467-023-44676-z
Yan, M. (2024). Emerging opportunities and challenges for the future of reservoir computing. Nature Communications, 15(1). https://doi.org/10.1038/s41467-024-45187-1
Yue, G. (2024). Boundary Refinement Network for Colorectal Polyp Segmentation in Colonoscopy Images. IEEE Signal Processing Letters, 31(Query date: 2026-03-26 14:10:35), 954–958. https://doi.org/10.1109/LSP.2024.3378106
Zhao, F. (2024). Deep Multimodal Data Fusion. ACM Computing Surveys, 56(9). https://doi.org/10.1145/3649447
Zhu, C. (2024). Computational intelligence-based classification system for the diagnosis of memory impairment in psychoactive substance users. Journal of Cloud Computing, 13(1). https://doi.org/10.1186/s13677-024-00675-z