TUMOR MICROENVIRONMENT-RESPONSIVE NANOMEDICINE FOR ENHANCED CANCER THERAPEUTICS

Muntasir Muntasir; Amin Zaki; Faisal Razak

doi:10.70177/jbtn.v3i5.4285

Muntasir Muntasir ⁽¹⁾, Amin Zaki ⁽²⁾, Faisal Razak ⁽³⁾

(1) Universitas Nusa Cendana,

Indonesia,

(2) Universiti Islam,

Malaysia,

(3) Universiti Malaya,

Malaysia

https://doi.org/10.70177/jbtn.v3i5.4285

Issue
Vol. 3 No. 5 (2026)

Submitted
August 1, 2026

Published
October 13, 2026

Keywords:

Cancer Therapeutics, Multidrug Resistance, Nanomedicine, Targeted Drug Delivery, Tumor Microenvironment

PDF

Abstract

The tumor microenvironment (TME) plays a critical role in cancer progression, drug resistance, and metastasis. As a result, targeting the TME with nanomedicine has become a promising strategy to enhance the efficacy of cancer therapeutics. This research explores the development of tumor microenvironment-responsive nanomedicine as a means to selectively deliver therapeutic agents to the tumor site, thus minimizing off-target effects and improving therapeutic outcomes. The primary goal of this study is to design and evaluate nanomedicine systems that can respond to specific factors within the TME, such as pH, enzymes, and hypoxia. The study employs a combination of in vitro and in vivo techniques, including cellular assays, animal models, and advanced imaging techniques, to assess the response of the nanomedicine to the tumor microenvironment and its therapeutic efficacy. The results indicate that the tumor microenvironment-responsive nanomedicine significantly enhances drug delivery, improving tumor targeting and reducing systemic toxicity. Furthermore, the nanomedicine shows a remarkable ability to overcome multidrug resistance, making it a promising candidate for enhancing the effectiveness of existing cancer therapies. In conclusion, tumor microenvironment-responsive nanomedicine presents a novel and effective strategy for cancer treatment, offering a targeted approach that holds potential for improved therapeutic outcomes in cancer patients.

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Authors

Muntasir Muntasir

Universitas Nusa Cendana

muntasir@staf.undana.ac.id (Primary Contact)

Amin Zaki

Universiti Islam

Faisal Razak

Universiti Malaya

Muntasir, M., Zaki, A., & Razak, F. (2026). TUMOR MICROENVIRONMENT-RESPONSIVE NANOMEDICINE FOR ENHANCED CANCER THERAPEUTICS. Journal of Biomedical and Techno Nanomaterials, 3(5), 337–347. https://doi.org/10.70177/jbtn.v3i5.4285