SMART NANOMEDICINE SYSTEMS FOR PRECISION DRUG RELEASE AND REDUCED TOXICITY
Kazakhstan Kazakhstan 
Indonesia 
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Controlled Release, Drug Delivery, Precision Medicine, Reduced Toxicity, Smart Nanomedicine
Abstract
The development of smart nanomedicine systems has revolutionized the field of drug delivery, offering improved precision in targeting diseased tissues and minimizing the side effects of treatments. Traditional drug delivery methods often suffer from non-specific targeting and high systemic toxicity, limiting their therapeutic potential. Smart nanomedicine systems, designed to respond to specific stimuli such as pH, temperature, or enzymes, allow for controlled and targeted drug release, thus enhancing therapeutic efficacy while reducing off-target effects. This research investigates the design, characterization, and application of smart nanomedicine systems for precision drug release and reduced toxicity. The primary objective of this study is to evaluate the efficiency of these systems in delivering drugs to specific sites, such as tumors, while minimizing damage to healthy tissues. In vitro and in vivo models are used to assess the release profiles, bio-distribution, and toxicity of the nanomedicine systems. The results show that smart nanomedicine systems significantly enhance drug accumulation at target sites and reduce systemic toxicity compared to conventional delivery methods. In conclusion, the use of smart nanomedicine systems offers a promising approach for precision medicine, improving therapeutic outcomes and reducing adverse effects associated with traditional drug delivery.
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References
Abdoh, A., Imran, M., Al-Smadi, K., Kaur, H., Ali, M., Kumeria, T., & Mohammed, Y. (2026). Stimuli-responsive smart nanocarriers for skin drug delivery. International Journal of Pharmaceutics, 691, 126534. https://doi.org/10.1016/j.ijpharm.2025.126534
Ahmad, Q., Mehdi, S., Shaukat, B., Siddique, R., Asif, M. T., Malik, A., Khan, S., Siddiqui, R., Khan, N. A., & Mehmood, M. H. (2026). Multi-stimuli responsive nanoparticles: Next-generation platforms for smart drug delivery. OpenNano, 29, 100296. https://doi.org/10.1016/j.onano.2026.100296
Alam, M. A. (2026). Emerging smart nanocarrier based drug delivery systems for cancer therapeutics. Next Nanotechnology, 9, 100387. https://doi.org/10.1016/j.nxnano.2026.100387
Bajgiran, N. K., Ahmadi, Y., & Majidi, S. (2025). Smart nanoparticles for responsive drug delivery in Diabetes: Advances, Challenges, and future Perspectives. International Journal of Pharmaceutics, 681, 125817. https://doi.org/10.1016/j.ijpharm.2025.125817
Cagil, E. M., Yakhshilikova, L., & Ersoz, M. (2026). Smart bioconjugated MOFs for targeted drug delivery: Albumin and globulin effects on mebeverine release dynamics. Nanomedicine: Nanotechnology, Biology and Medicine, 71, 102882. https://doi.org/10.1016/j.nano.2025.102882
Chen, Y., Guo, Z., Li, J., Wang, K., & Huang, J. (2025). Smart nucleic acid nanodrug delivery system for precision therapeutics. Coordination Chemistry Reviews, 535, 216673. https://doi.org/10.1016/j.ccr.2025.216673
Chowdhury, S., Sarkar, S., Das, A., Kar, K., & Chakraborty, P. (2026). Next-generation smart drug delivery: Biosensor-integrated closed-loop therapeutics (CLT) for regenerative medicine. Next Bioengineering, 2, 100027. https://doi.org/10.1016/j.nxbio.2026.100027
Datta, D., Colaco, V., Nison, M., H, A. P., Bandi, S. P., Dhas, N., Pai, V. R., Halagali, P., Tippavajhala, V. K., Singh, S., & Vora, L. K. (2026). Smart microdevices for biomedical drug delivery: Endogenous stimuli as the key to safer therapeutics. RSC Advances, 16(16), 14878–14935. https://doi.org/10.1039/d5ra09767c
Davarpanah, F., Safari, J., & Masaeli, E. (2026). Injectable smart hydrogel with dual pH/thermal responsiveness: A PCL–PEG–PCL/niosome synergistic platform for precision drug delivery. Biomaterials Advances, 179, 214527. https://doi.org/10.1016/j.bioadv.2025.214527
Deepti, A., Jose, J., Saidumohamed, B. E., & Govind, S. (2026). Chapter 14—Smart systems for the management of cerebrovascular accidents: Integrating artificial intelligence with targeted drug delivery. In C. P. Sharma, F. G. Thankam, & R. Goswami (Eds.), AI Powered Drug delivery to Neuro and Cardiovascular Systems (pp. 371–405). Academic Press. https://doi.org/10.1016/B978-0-443-40441-2.00003-2
Emadi, R., Amiri, Z., Mortazavi Moghadam, F., Raoufi, S., Zargar Moradi, M., Asadi, S., C. Cho, W., Park, J. H., Voosough, A., Ramezani Farani, M., Hwang, S.-K., & Huh, Y. S. (2026). Self-assembling nanocomposites for smart drug delivery: Towards personalized and stimuli-responsive therapeutics. RSC Advances, 16(6), 5088–5127. https://doi.org/10.1039/d5ra07117h
Esmaeilpour, D., Ghavami, S., Zarrabi, A., Khosravi, A., Zarepour, A., Cordani, M., Klionsky, D. J., Hamblin, M. R., & Sillanpää, M. (2026). Artificial-intelligence-guided autophagy modulation and nanomedicine design for precision photodynamic cancer therapy. Drug Discovery Today, 31(3), 104633. https://doi.org/10.1016/j.drudis.2026.104633
Filiz, A., Ölçero?lu, B., Çiçek, ?evval, Ayd?n Turna, S., Çetintürk, K., & Barlas, F. B. (2026). Engineering smart nanoplatforms for doxorubicin: Recent advances in stimuli-responsive drug delivery systems. Journal of Drug Delivery Science and Technology, 122, 108452. https://doi.org/10.1016/j.jddst.2026.108452
Fu, Z., Zhou, D., Liu, Z., & Ni, D. (2025). GSH-responsive nanomedicine for disease smart imaging and therapy. Coordination Chemistry Reviews, 533, 216554. https://doi.org/10.1016/j.ccr.2025.216554
Guo, F., & Pan, Y. (2025). Targeting lung cancer utilizing smart nanoparticles: Nanomedicine meets tumor stroma. Bioorganic Chemistry, 167, 109202. https://doi.org/10.1016/j.bioorg.2025.109202
Hassan, A., Zameer, M. D., Khan, M., Hassan, T., Umair, M., Iqbal, M. N., Ahi, M. J., Gul, P., & Ahmed, N. (2026). Smart nanocarriers for biosimilars: A new frontier in targeted drug delivery. Journal of Drug Delivery Science and Technology, 116, 107955. https://doi.org/10.1016/j.jddst.2025.107955
Hu, S., Zhao, R., Yang, S., Li, Y., Yin, W., Yu, S., Lyu, B., & Shen, Y. (2026). Smart nanodelivery systems for overcoming nitric oxide instability and enabling disease specific therapies. Applied Materials Today, 48, 103058. https://doi.org/10.1016/j.apmt.2025.103058
Hu, Y., Yang, X., Shu, F., Jin, L., Sarsaiya, S., Han, S., & Chen, J. (2026). Smart exosomes: Multimodal engineering strategies for logic-gated and stimuli-responsive precision theranostics. International Journal of Pharmaceutics, 698, 126846. https://doi.org/10.1016/j.ijpharm.2026.126846
Huang, X., Ji, M., Shang, X., Zhang, H., Zhang, X., Zhou, J., & Yin, T. (2025). Smart on-demand drug release strategies for cancer combination therapy. Journal of Controlled Release, 383, 113782. https://doi.org/10.1016/j.jconrel.2025.113782
Jain, M., Sheikh, A., Alqahtani, T., Shmrany, H. A., Gupta, G., Goh, K. W., & Kesharwani, P. (2026). Dextran-engineered smart nanosystems for intelligent tumor drug targeting. Critical Reviews in Oncology/Hematology, 220, 105173. https://doi.org/10.1016/j.critrevonc.2026.105173
Kar, N. P., Lin, J., HassankhaniRad, A., Li, W., Aboushanab, A. R., Li, Y., & Sun, J. (2025). Smart polymeric nanoparticles for targeted delivery and microenvironment-responsive therapy in pancreatic cancer. Smart Materials in Medicine, 6(3), 368–386. https://doi.org/10.1016/j.smaim.2025.09.003
Khan, S., Saeed, M., Gupta, G., Alsayari, A., Wahab, S., Goh, K. W., & Kesharwani, P. (2025). Smart nanoparticle delivery systems for resveratrol: A targeted strategy to enhance anticancer efficacy and bioavailability. Microchemical Journal, 218, 115307. https://doi.org/10.1016/j.microc.2025.115307
Khatri, D., Wani, B. G., Mir, M., Chauhan, A., & Chauhan, D. (2026). Chapter 6—Advanced drug delivery strategies: Nanoparticles, liposomes, dendrimers, and smart biomaterials. In S. Banerjee & D. Bhatia (Eds.), Novel and Innovative Drug Delivery Systems to Overcome Chemoresistance in Human Malignancies (pp. 145–167). Academic Press. https://doi.org/10.1016/B978-0-443-45717-3.00001-5
Li, X., Yu, W., Zhang, Y., Zhao, H., Wang, J., Sun, M., Xing, D., & Wang, C. (2026). Tumor microenvironment-responsive self-assembled drug-drug conjugate nanosystems: A smart platform for precision cancer therapy. Coordination Chemistry Reviews, 547, 217097. https://doi.org/10.1016/j.ccr.2025.217097
Liang, C., Zhang, T., Zhang, Q., & Mou, X. (2025). Smart self-assembled nanomedicine for ferroptotic tumor therapy. Colloid and Interface Science Communications, 66, 100829. https://doi.org/10.1016/j.colcom.2025.100829
Mousavi, S. M., Abbasifard, M., Abbasi, R., Tivay, S., Hosseini, H., Taghipoor, M., Kalashgrani, M. Y., Aljabri, M. D., Rahman, M. M., Chiang, W.-H., & Ghahramani, Y. (2025). Smart nano exosomes as precision drug carriers: A new frontier in targeted treatment of oral cancer. International Journal of Pharmaceutics, 682, 125923. https://doi.org/10.1016/j.ijpharm.2025.125923
Singh, M., Singh, S., Sharma, P., Bhandari, R., Sharma, N., Rajput, R., Gupta, V., Singh, S. K., Dua, K., Chitranshi, N., & Basu, S. (2026). Smart Lipid-Based Nanocarrier System for the Topical Delivery of Ocular Therapeutics Bio-Interfacing, Physicochemical Diversity, and Routing Barriers. European Journal of Pharmaceutical Sciences, 107506. https://doi.org/10.1016/j.ejps.2026.107506
Soleymani, S., Naghib, S. M., & Mozafari, M. R. (2025). pH/ Temperature/ Redox and Light-responsive Polymersome Structure and Application in Cancer Therapy: Smart Drug Delivery and Targeted Drug Release. Current Medicinal Chemistry, 32(22), 4456–4480. https://doi.org/10.2174/0109298673303351240507113603
Tan, J., Geng, W., Ju, T., Liu, S., Chen, Z., Li, P., Liu, K., Liu, X., Zhao, Q., Wang, K., & Liu, H. (2026). From natural product to nanomedicine: Advances in smart capsaicin delivery systems for the treatment of complex diseases. Sustainable Materials and Technologies, e02095. https://doi.org/10.1016/j.susmat.2026.e02095
Verma, A. K., Singh, A., Singh, A. K., Maurya, P. S., Jaiswal, V., & Sachan, V. (2026). Precision veterinary therapeutics through nanomedicine: Platforms, applications, and One Health implications. Next Research, 9, 101747. https://doi.org/10.1016/j.nexres.2026.101747
Wang, Z.-X., Wang, S.-Y., Wang, Z., Liu, Y., & Wu, F.-G. (2026). Smart photo-enabled micelles for cancer therapy: Mechanisms, challenges, and innovations. Journal of Controlled Release, 390, 114474. https://doi.org/10.1016/j.jconrel.2025.114474
Yazdani, S., Mozaffarian, M., Pazuki, G., & Hadidi, N. (2026). Artificial intelligence-assisted design and optimization of stimuli-responsive nanocarriers for smart drug delivery. Materials Today Bio, 38, 103153. https://doi.org/10.1016/j.mtbio.2026.103153
Younas, A., Wang, S., Asad, M., Al Mamun, A., Majeed, S., Sharif, A., Zhou, Q., Liu, Y., Geng, P., Shao, C., & Xiao, J. (2026). Recent advances in cancer nanomedicine: From smart targeting to personalized therapeutics—Pioneering a new era in precision oncology. Materials Today Bio, 36, 102660. https://doi.org/10.1016/j.mtbio.2025.102660
Zhang, P., Pan, J., Lin, S., Peng, B., An, C., Zhang, J., Xu, L., Lai, Y., Yu, H., & Xu, Z. (2025). Smart drug delivery platforms reprogramming cancer immune cycle to mitigate immune resistance of pancreatic tumors. Advanced Drug Delivery Reviews, 224, 115620. https://doi.org/10.1016/j.addr.2025.115620
Zhao, Y., Zhang, Z., Yang, X., & Li, Z. (2025). Progress on hydroxyethyl starch-based smart nanomedicines. Precision Medicine and Engineering, 2(3), 100041. https://doi.org/10.1016/j.preme.2025.100041
Zhu, R., Yu, X., Zhang, Y., Zhang, J., Li, S., Li, D., & Ma, Y. (2026). Smart stimuli-responsive polymeric nanoparticles in precision cancer therapy: From tumor microenvironment triggers to controlled release. Chemical Engineering Journal, 534, 175025. https://doi.org/10.1016/j.cej.2026.175025
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Copyright (c) 2026 Assel Zhanibek, Samat Yessentayev, Muntasir Muntasir
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